Retatrutide
Research use only.
Retatrutide is one of the newest and most talked-about research peptides in the weight and metabolism field. It is a lab-made molecule that works on three of the body's appetite and blood-sugar hormones at the same time — GIP, GLP-1 and glucagon — which is why researchers often call it a "triple agonist."
What makes it different
Most earlier peptides in this area work on only one or two of these hormone pathways. Retatrutide is studied because it targets all three at once. That extra glucagon lever is thought to affect how much energy the body burns, on top of the appetite and blood-sugar effects — and that combination is what has made its trial results stand out.
What it is studied for
- Appetite: how it helps reduce hunger and food intake.
- Weight management: the main focus of its clinical trials.
- Metabolism: its effects on blood sugar and how the body uses fat.
How it compares to semaglutide and tirzepatide
A simple way to picture it: semaglutide works on one hormone pathway (GLP-1), tirzepatide works on two (GLP-1 and GIP), and retatrutide works on all three by adding glucagon. Each step adds another lever for researchers to study.
Storing and mixing it (for lab use)
Retatrutide ships as a freeze-dried powder. Kept sealed, cold and out of the light, it stays stable for a long time. For research work it is mixed (reconstituted) with bacteriostatic water, then kept refrigerated. Our on-site peptide calculator can help work out mixing amounts.
What you get from us
Every batch is HPLC-tested and comes with its own Certificate of Analysis (COA), so you can confirm identity and purity before you begin. We ship across Canada, usually within 1–3 business days by Xpresspost.
Common questions
Is retatrutide an approved medicine? No. It is still investigational and is being studied in clinical trials. We supply it strictly as a research compound — not for human or animal use.
What does "triple agonist" mean? It simply means the molecule switches on three hormone receptors (GIP, GLP-1 and glucagon) instead of one or two.
Do you include a COA? Yes — every batch has its own Certificate of Analysis you can view before buying.
Do you ship to me? We ship within Canada only.
Research use only. Not for human or veterinary use. Nothing here is medical advice.
About Retatrutide
Retatrutide (LY3437943) is a single peptide engineered to activate three receptors at once: GIP, GLP-1 and glucagon. That triple-agonist design makes it one of the most closely watched compounds in current metabolic and receptor-pharmacology research, where it is compared against single (semaglutide) and dual (tirzepatide) agonists.
Key research areas
- Triple receptor agonism — Combined GIP, GLP-1 and glucagon-receptor signalling.
- Incretin research — How GIP and GLP-1 co-agonism compares with single agonists.
- Glucagon-receptor effects — Energy-expenditure and hepatic-metabolism research.
- Comparative pharmacology — Benchmarked against semaglutide and tirzepatide.
Specifications
| Compound class | GIP/GLP-1/glucagon triple-agonist peptide |
| Form | Lyophilized powder |
| Sizes | 10mg · 20mg |
| Purity | ≥99% (HPLC), per-batch COA |
| Storage | Lyophilized: store at −20 °C, protected from light. After reconstitution: 2–8 °C. |
Frequently asked questions
What makes retatrutide different from tirzepatide and semaglutide?
Semaglutide targets GLP-1 only; tirzepatide targets GIP and GLP-1; retatrutide adds the glucagon receptor as a third target.
Do your retatrutide vials have a temperature indicator?
Our 20mg vials carry a built-in temperature strip: pink/magenta when fridge-cold, white at room temperature.
Does every batch include a COA?
Yes. Every batch is HPLC-tested and ships with its own certificate of analysis.
Is retatrutide for human use?
No. It is sold strictly for laboratory research use only and is not approved for human use.
Related research compounds
Comparing incretin compounds? See our GLP-1 research peptides guide, which compares retatrutide, tirzepatide, semaglutide and cagrilintide side by side.
For laboratory research use only. Not for human or veterinary consumption.
Customer reviews
All products are sold strictly for laboratory and research use only — not for human or veterinary use, consumption, or therapeutic application. By purchasing you confirm you are a qualified researcher and accept full responsibility for safe handling and compliance with applicable laws.